The Big Finding
You'd expect a showdown between whey, pea and egg protein to crown a clear winner. This one didn't, and the reason is more interesting than a simple ranking.
A University of Vienna team pooled 51 tracer-based trials to compare how different protein sources stimulate muscle protein synthesis (MPS) after resistance training. Several proteins, animal and plant, landed close together. Yet only one, standard whey protein, produced a statistically significant effect.
How the Study Was Built
The paper, published in the Journal of the International Society of Sports Nutrition (2026), is a systematic review with both standard and dose-response network meta-analyses (NMAs). A network meta-analysis lets researchers compare treatments that were never tested head-to-head by linking them through shared comparators.
- Searches: PubMed, EBSCOhost (MEDLINE, SPORTDiscus, CINAHL) and Scopus.
- Participants: healthy adults aged 18 or older.
- Protocol: an acute bout of resistance exercise followed by a single protein bolus, with no additional food in between.
- Measurement: muscle biopsies before and after, with hourly MPS rates measured via tracer techniques.
- Exclusions: protein blends and products enriched with other anabolic agents.
- Sample: 51 trials met the criteria.
The authors reported no conflicts of interest.
The Leaderboard
Proteins were ranked by P-score, a 0-to-1 value reflecting the estimated likelihood of ranking high for post-exercise hourly MPS:
| Protein | P-score | Mean difference (%/h) |
|---|---|---|
| Native whey | 0.81 | 0.05 [0.00; 0.10] |
| Pea | 0.77 | 0.05 [-0.02; 0.11] |
| Whole egg | 0.72 | 0.04 [-0.01; 0.09] |
| Mycoprotein | 0.66 | 0.03 [-0.02; 0.08] |
| Whey | 0.58 | 0.02 [0.01; 0.04] |
The certainty of evidence was rated low to moderate.
Why the Lowest-Ranked Protein Was the Only "Significant" One
This is the twist. Standard whey ranked fifth of the five, yet it alone had a confidence interval that excluded zero (0.01 to 0.04). Native whey, pea, egg and mycoprotein all had point estimates as large or larger, but their intervals were wide enough to include zero or only touched it.
The likely explanation is statistical precision, not superior biology. Whey is studied constantly, so its estimate is tight. Pea and mycoprotein are represented by far fewer trials, so their estimates are fuzzy. The authors say as much: sources backed by few studies should be interpreted with caution.
P-scores also show rank, not magnitude. A rank of 0.77 for pea does not mean pea is proven to work. It means that, given the data available, pea tends to sit near the top.
The Dose Sweet Spot: 18 to 25 Grams
The dose-response analysis found the highest predicted MPS responses at 18 to 25 g for native whey, whole egg, pea and mycoprotein. Both animal and plant sources appeared in that range, which suggests dose may matter as much as source for the acute response.
What This Means for You
Dose: Aim for roughly 18 to 25 g of protein in a post-workout serving. That is where the model predicted peak MPS for the best-performing sources.
Timing: The trials tested a single bolus after resistance exercise. The paper supports a post-workout serving but doesn't define an exact "anabolic window", so don't stress over minutes.
- Lifters who tolerate dairy: whey has the most statistically solid evidence here.
- Plant-based or dairy-avoidant lifters: pea and mycoprotein looked competitive in rank and dose-response, which is encouraging, though the evidence is thinner.
- Egg eaters: whole egg ranked third and fit the same dose range.
Who should skip or be cautious:
- Anyone with a dairy, egg or pea allergy should obviously avoid that source.
- People with kidney disease or other medical conditions affecting protein intake should check with a clinician before changing their intake.
- Anyone expecting this paper to justify a particular brand or blend. Blends were excluded, so multi-source plant mixes (such as pea plus rice) weren't evaluated.
Important Limits
Acute MPS isn't muscle growth. These trials measured short-term protein synthesis rates, not months of training. A higher MPS reading in a few hours doesn't guarantee more muscle or strength over time, since total daily protein, training quality, calorie intake and recovery all contribute.
The differences are small. Mean differences ranged from 0.02 to 0.05 percentage points per hour. That is statistically measurable but not necessarily meaningful in practice.
Evidence quality is modest. Low to moderate certainty means future trials could shift the rankings, especially for the less-studied proteins.
The Bottom Line
No protein dethroned whey, but none was ruled out either. Whey is the only source with a statistically significant effect in this analysis, while pea, mycoprotein and whole egg look like credible alternatives that need more research. If you want a simple plan, take a 18 to 25 g protein serving after training from a source you tolerate and enjoy, and keep your daily total protein and consistent training in view, because those drive long-term gains.