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东革阿里:每日 400 mg、连续 5 周提升睾酮与握力

Dr. Gymbro · · 1 min read

东革阿里:每日 400 mg、连续 5 周提升睾酮与握力

东革阿里是网络搜索量最高的睾酮提升剂之一。一项小规模的先导研究为其提供了真实的人体数据:25 名年龄在 57‑72 岁、身体活跃的成年人每日服用 400 mg 提取物,连续 5 周后,总睾酮、游离睾酮均显著上升,握力也随之增强。女性的游离睾酮同样提升,作者认为这与 SHBG 下降有关。由于缺乏安慰剂对照,这项研究更像是前景可期的信号,而非确凿证据。下面将介绍研究的发现、它无法解答的部分,以及如何理性看待。

研究概况

这篇论文题为《东革阿里作为一种潜在的体力活跃老年男女草本补充剂:先导研究》,作者包括 Henkel RR、Wang R、Bassett SH、Chen T、Liu N、Zhu Y 与 Tambi MI,发表于 Phytotherapy Research(2014 年,Epub 2013),已被收录于 PubMed(DOI: 10.1002/ptr.5017)。

研究招募了 13 名体力活跃的男性和 12 名体力活跃的女性,年龄在 57‑72 岁,每位受试者每日摄入 400 mg 东革阿里(Eurycoma longifolia)提取物,持续 5 周。

监测指标包括:

  • 总睾酮与游离睾酮
  • 脱氢表雄酮(DHEA)
  • 皮质醇
  • 类胰岛素生长因子‑1(IGF‑1)
  • 性激素结合球蛋白(SHBG)
  • 血尿素氮(肾功能指标)
  • 肌酸激酶(肌肉损伤指标)
  • 标准血常规
  • 肌肉力量(简易握力测试)

结果:到底发生了什么

最显著的发现是,该处理显著提升了男女受试者的总睾酮、游离睾酮以及握力。作者据此认为东革阿里具备增效(ergogenic)作用。

需要注意的细节包括:

  • 男女之间仍存在差异。 处理后,女性的血红蛋白、睾酮、DHEA、总睾酮/皮质醇比值以及握力仍显著低于男性。女性虽有提升,但未能追平男性。
  • 女性游离睾酮上升归因于 SHBG 下降。 SHBG 是血浆中与睾酮结合的蛋白,浓度下降会导致游离睾酮比例增高。
  • 男性的红细胞指标略有上升。 血细胞比容和红细胞计数在男性中出现轻微增加,并显著高于女性。

摘要未给出具体的百分比变化或激素数值,本文也不作引用。可以确认的“硬数据”只有:25 人、每日 400 mg、5 周,以及睾酮和力量的显著提升方向。

可能的作用机制

论文的出发点是东革阿里已被报道能够提升睾酮并缓解男性衰老症状。唯一在摘要中提到的机制是 女性 SHBG 的下降——结合蛋白减少意味着更多游离、可利用的睾酮。这是一个合理的线索,但研究并未专门设计验证具体的作用路径,任何超出此范围的解释都属于猜测。

测量握力是有道理的,因为睾酮与肌肉功能相关,激素上升伴随力量提升符合逻辑。但本研究无法证明两者之间的因果关系。

局限性:前景可期,尚未证实

这是一项 小规模、无对照的先导研究,解读时需注意以下几点:

  • 没有安慰剂组。 前后对比设计无法排除心理暗示、练习效应或自然波动的影响。
  • 样本量仅 25 人。 按性别拆分后每组更是微乎其微,统计力量受限。
  • 受试者为活跃的 57‑72 岁成年人。 老年人基线睾酮较低,提升空间更大。年轻力量训练者的反应可能截然不同且幅度更小。
  • 握力测试范围有限。 该指标不能直接推断深蹲、卧推或硬拉等复合力量项目的变化。
  • 仅 5 周。 长期安全性和效果的持久性仍未知。
  • 男性红细胞指标的轻微变化 提醒我们在使用时仍应监测血常规,而非盲目认为完全无害。

作者将其称为先导研究并标记为“潜在”补剂,正是因为它为更大规模、对照严谨的试验提供了依据,而非最终结论。

适用人群与禁忌

可能感兴趣的群体:活跃的成年人,尤其是年长的力量训练者,希望尝试一种有一定人体数据支撑的天然选项,并愿意将其视作实验对象。

应谨慎或避免的人群:

  • 正在服用处方药的人,因为药物相互作用尚未系统评估;
  • 有激素敏感疾病的人;
  • 有血液或肾功能问题的人,因为研究中特别监测了相关指标;
  • 期望获得类类固醇效果的人——本研究并不支持此类期待。

实用建议

  • 研究中使用的剂量:每日 400 mg 东革阿里提取物。
  • 使用时长:5 周;研究未提供更长期的数据。
  • 服用时间:摘要未说明具体服用时间点,暂无证据表明特定时间更佳。
  • 产品质量至关重要:市面上补剂差异大,选购时应寻找标准化提取物并具备第三方检测报告,确保剂量与研究相符。
  • 先咨询医生,尤其是有用药或激素相关疾病史的情况。若决定尝试,进行基线和随访血液检查是明智之举。
  • 先把基础打好:系统的训练、充足的蛋白质摄入、良好睡眠和合理热量摄入,对力量提升的贡献远大于任何草本。

结论

东革阿里因本研究的 “小幅提升” 而声誉进一步上升:25 位活跃的老年受试者每日摄入 400 mg,连续 5 周后,睾酮和握力均出现显著提升。但由于缺乏安慰剂对照且样本极小,这更像是对更大规模、严谨对照试验的呼唤,而非对 25 岁年轻举重者的直接预期。完整记录请参见 PubMed。

Original study

Read the original research on pubmed.ncbi.nlm.nih.gov →

This article summarizes published research for general information. It is not medical advice.

DG

Written by

Dr. Gymbro

Dr. Gymbro writes for Dr. Gymbro: science-backed fitness, nutrition & performance.

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