Karin Da Ya Kara Sha Arginine Da Kashi 17% A Wani Gwaji Karami

Arginine da aka sha kafin motsa jiki na iya rasa wani bangare na fa'ida. Wani gwajin crossover da aka gudanar a 2023 ya gano cewa haɗa gram 5 na arginine da kapsul ɗin Astragalus da Panax notoginseng saponins (APS) ya ƙara shakar arginine kuma ya canza wasu alamomin nitric oxide (NO). Alamar arginine/ADMA ta ƙaru 167.1 % – abu da ke nuni da yanayi mafi kyau ga samar da NO.

Kafin ka ƙara wani abu a cikin shakar ka, ga abin da binciken ya nuna da abin da ba ya nuna.

Menene Gaskiyar Binciken

Takardar da aka wallafa a Functional Foods in Health and Disease (2023; 13(6):307‑319, rajista a matsayin NCT05024123) ta bayyana wannan randomized, double‑blind, placebo‑controlled crossover pharmacokinetic study. Mutane masu lafiya tsakanin shekaru 20 zuwa 80 sun sha gram 5 na foda arginine tare da ko dai kapsul ɗin APS ɗaya ko kuma placebo. Kowanne mahalarta ya gwada duka yanayi biyu, tare da lokaci na wankewa a tsakani. Masana sun tattara plasma da fitsari don bin diddigin matakin arginine da alamomin da suka shafi NO.

Masu rubutun sun ce ba su san wani gwajin ɗan adam da aka yi a baya kan haɗin Astragalus da ginseng a kan matakan NO ba, don haka wannan aiki ne na mataki na farko.

Lambobin Da Suka Fice

Idan aka kwatanta arginine tare da placebo, arginine tare da APS ya haifar da:

• Arginine AUC +17.3 % (p = 0.041). AUC na nufin jimillar shigarwa, don haka wannan sakamakon na “ƙara shakar arginine”.
• Arginine C_max +11.1 %. Wannan shine kololuwar matakin a cikin jini. Takaitaccen bai ba da p‑value ba.
• Arg/ADMA ratio +167.1 % (p = 0.007). ADMA (asymmetric dimethylarginine) yana ƙin enzyme da ke samar da NO, don haka ƙaruwa a wannan alaka na nuni da yanayi mafi kyau ga samar da NO.
• Urinary nitrate +20.8 % da urinary cGMP +18.9 %. Duka biyun alamomi ne a ƙasa da NO. Takaitaccen bai ba da ƙimar muhimmanci ga waɗannan ba.

Masu rubutu sun kammala da cewa APS ya inganta shakar arginine, ya rage ADMA, kuma ya ƙara samar da NO.

Me Ya Sa Masu Motsa Jiki Zasu Damu (Kuma Me Ya Sa Kada Su Yi Wahalhalu)

Arginine na daga cikin manyan sinadarai na pre‑workout saboda shi ne tushen NO, wanda ke taimakawa wajen sassautar jijiyoyi. Koyaya, wasu sun yi korafi cewa shan arginine daga baki ba koyaushe yake haifar da ƙaruwa a matakin NO ba. Idan wani abu zai iya ƙara shakar arginine kuma ya rage ADMA, tabbas zai iya zama abin sha’awa ga masu motsa jiki. Masu rubutun sun ba da shawarar APS na iya amfanar da pre‑workout da lafiyar zuciya.

Amma wannan shawarar ta wuce abin da bayanai suka nuna. Wannan bincike ya auna alamomin jini da fitsari ne kawai. Ba a gwada aiki a lokacin motsa jiki – kamar ƙarfi, juriya, ko “pump” – ba. Ba wanda ya sami ƙaruwa a ainihin aiki. Alamomin NO da aka auna ba sa nufin an samu ƙara a ƙarfi ko aiyuka.

Kuskuren Da Ya Kamata Ka San

1. An cire mutane shida. An yi rajista da mutane 30, amma bayan cire waɗanda amsoshin su suka bambanta sosai, an rage zuwa 24 – wato kashi 20 % na samfurin. Cire mutane saboda “bambancin kai‑da‑kai” na iya sanya sakamakon ya zama mai tsafta fiye da ainihi, amma ba a fayyace yadda aka yanke wannan shawara ba.
2. Samfurin ƙarami. Mutane 24 ba su da yawa, kuma p‑value na AUC (0.041) yana kan iyakar shigar da ƙa’ida.
3. Masu lafiya kawai. Ba a haɗa da masu cutar zuciya, hawan jini, ko waɗanda ke ɗaukar magunguna ba.
4. Tsarin guda‑daya. Takaitaccen ya bayyana gram 5 na arginine + kapsul ɗin APS ɗaya. Ba a ba da bayanin tsawon lokacin amfani ko maimaitawa ba.
5. Alamomin wakili ne. Nitrate a fitsari da cGMP ba su auna aikin jijiyoyi kai tsaye ba; su ne alamomin NO ne kawai.
6. Bayanai marasa cikawa. Takaitaccen ba ya ƙunshi adadin saponin a cikin kapsul, farashin samfur, ko wasu muhimman bayanai. Don haka ya kamata ka duba takardar asali idan kana son ƙarin bayani.

Abubuwan Da Za Su Amfane Ka

• Gwajin da aka yi: gram 5 na foda arginine tare da kapsul ɗin APS ɗaya. Idan ba a ba da adadin saponin a cikin kapsul ba, ba za a iya maimaita gwajin ba.
• Lokacin ɗauka: Takaitaccen ba ya fayyace tsawon lokacin da ake jira kafin motsa jiki ko ko an yi wani motsa jiki a lokacin gwajin. Kada ka ɗauka cewa akwai wani “window” na musamman da aka tabbatar da shi.
• Waɗanda za su iya amfani da shi: Mutane masu lafiya, daga shekaru 20 zuwa 80, da ke riga suna shan arginine kuma suna son ƙara yawan shakar sa.
• Waɗanda ya kamata su guje shi ko su tuntuɓi likita kafin su yi amfani:
  • Duk wanda ke da matsalar zuciya, hawan jini, ko ke ɗaukar magungunan zuciya.
  • Duk wanda ke shan maganin jini ko wasu magunguna masu tasiri a kan jijiyoyi.
  • Mata masu juna biyu ko masu shayarwa, da kuma kowa da ke da wata cuta mai tsanani.
  • Duk wanda ke tsammanin zai samu ƙaruwa a aiki, saboda ba a gwada ainihin aiki a wannan bincike ba.

Takaitaccen ba ya maganar farashi, don haka kiran shi "karo mai araha" ba shi da tushe.

Gabaɗaya

Wannan ƙaramar, amma an sarrafa sosai, crossover trial ya ba da alamar farko mai ƙarfi cewa APS na iya inganta yadda jiki ke sarrafa ƙarin arginine da kuma inganta alamar NO. Tsallaken 167 % a alaƙar Arg/ADMA babban abu ne da ya kamata a lura da shi. Sai dai, cire mutane shida, ƙaramin samfur, rashin ƙimar wasu alamomi, da kuma rashin bayani kan tasirin a kan aikin motsa jiki, suna sanya wannan bincike ya kasance a matakin ƙirƙirar tunani – ba dalilin canza duka kayan gina jikinka ba. Mataki na gaba shi ne gwaji mafi girma da zai haɗa da auna aiki a lokacin motsa jiki da kuma ainihin sakamakon ga kowa da kowa.