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#paraxanthine

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science research

Paraxanthine vs Caffeine: The Combo That Won, and the Sleep-Saver

BY DR. GYMBRO ·

Paraxanthine, caffeine's main metabolite, just went head-to-head with caffeine in a trial of 14 rowers. The combo of 200 mg each beat placebo on a 2000-m row, but only with a small effect (d = 0.30). Neither compound alone clearly improved performance. Paraxanthine alone, however, looked friendlier to subjective sleep. Here are the numbers, the limits, and who might actually benefit.

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