Everyone wants to know if creatine can save your muscle when an injury puts you in a cast. A new systematic review of six randomised trials (118 young people, 1-2 weeks of immobilisation) says the evidence during disuse is mixed, and some apparent lean-mass benefits may just be water. The more intriguing signal came during rehab, where two studies found larger gains in quad size, power and strength with creatine. Here are the real numbers, the limitations, and who might want to try it.
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