Creatine is the most trusted supplement in the gym, but a 2024 study suggests it may also fight sleep-deprivation brain fog within hours. In the study, a single 0.35 g/kg dose, roughly 25-28 g for most adults, changed brain energy markers, prevented a drop in brain pH and improved cognitive performance and processing speed during 21 hours without sleep. That's about five times a normal 3-5 g daily dose, and the study was small and lab-based. GI upset is a real possibility, and nobody tested repeated mega-dosing. Here's what the research really shows, and why you shouldn't change your daily routine yet.
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