Paraxanthine vs Caffeine: The Combo That Won, and the Sleep-Saver
Paraxanthine, caffeine's main metabolite, just went head-to-head with caffeine in a trial of 14 rowers. The combo of 200 mg each beat placebo on a 2000-m row, but only with a small effect (d = 0.30). Neither compound alone clearly improved performance. Paraxanthine alone, however, looked friendlier to subjective sleep. Here are the numbers, the limits, and who might actually benefit.
Ketone Drinks in the Heat: Longer Endurance and Sharper Memory?
Ketone drinks are supposed to be for fat-burning biohackers, but a new heat-stress trial suggests they might also help you finish stronger. In 17 trained men, ketone monoester plus caffeine extended time to exhaustion to 8.9 minutes versus 7.0 with carbs plus caffeine, after 90 minutes of loaded treadmill work at 34 °C. Working-memory accuracy on the 1-back task improved too, while heart rate and core temperature didn't differ meaningfully. But 2-back, reaction time and the hit-and-avoid task showed no benefit, and the study was small, male-only and single-session. Here's what the data show, and what they don't.
Coffee Cherry Extract: 200 mg Caffeine Lifted Cycling Output 4.6%
A low 200 mg caffeine dose from whole coffee cherry extract helped trained cyclists produce 4.6% more work in a 15-minute time trial. But the popular idea that it speeds up glycogen refuelling didn't hold up. This randomized, double-blind crossover trial involved just 12 cyclists and was industry-funded, with no plain-caffeine comparison group. Here's what the data show, what they don't, and who might want to try it.
Your Energy Drink May Work Like a Pre-Workout—With One Catch
Caffeine and taurine sit side by side in energy drinks and pre-workouts, but does the pair actually boost performance? A new meta-analysis of 11 randomized trials (234 participants) found moderate improvements in peak power and time to exhaustion, plus lower perceived effort. Heart rate didn't budge, and the reaction-time result was too inconsistent to trust. The catch is that the studies were small and can't show whether taurine adds anything beyond caffeine. Here's what the data say, and who should think twice.
Doubling Your Caffeine Barely Helped Boxers—Here's What Did
Think a double scoop of pre-workout means double the performance? A new crossover trial in 15 competitive boxers compared 3 mg/kg and 6 mg/kg of caffeine, and the bigger dose was not consistently better. Both doses raised jump height and power at 60 minutes, while 6 mg/kg only pulled ahead on a few outcomes like ballistic push-up power and knee torque. Here is the mg-per-kg conversion for common body weights, the timing the data supports, and the honest caveats, including that punching itself was never tested.
Pre-Workout Caffeine Stiffens Arteries. Beetroot Powder Offset It
A new randomized crossover trial found that a pre-workout-sized dose of caffeine (6 mg/kg) raised markers of arterial stiffness within 2.5 hours. Adding a beetroot powder with 400 mg of nitrate brought those markers back to placebo levels. Blood pressure and endothelial function did not change, so this is a subtle effect rather than a red flag. The study involved just 24 healthy young adults and a single dose, leaving big questions about long-term use and older or hypertensive people. Here is what the data show, what they do not, and how to think about it if you rely on caffeine before training.
Low-Dose Caffeine Coffee Gave Elite Fighters Zero Sprint Boost
Think your pre-workout coffee is supercharging your sprints? A new randomized, double-blind crossover trial in 15 national-level combat athletes found no performance benefit from caffeine doses of 1.5 and 3 mg/kg, about 100 and 200 mg for a 68 kg athlete. Peak power, mean power, fatigue index and even estimated energy system contributions did not differ from decaf. But this is a small null result, not proof that caffeine fails, and most positive studies use capsules at 3–6 mg/kg. Here is the dose math, the caveats and what to actually do before your next hard session.
Guarana vs Caffeine: Same Dose, Only Guarana Lifted Peak Power
Same caffeine dose, different capsule, and only guarana produced a statistically significant boost in peak power. In a randomized crossover trial of 18 active men, guarana raised peak power output by 4.0% over placebo while anhydrous caffeine did not reach significance. But here's the catch: guarana didn't significantly beat caffeine head-to-head, and the differences between them were only descriptive. Here's what the numbers show, where the study falls short, and how to dose guarana by caffeine content if you want to try it.
Caffeine + Capsaicin Beat Placebo in a 10K. Capsaicin Alone Didn't
A chili-pepper compound plus caffeine was the only combo that beat placebo over 10 km in a new crossover trial, yet capsaicin alone did nothing. Caffeine drove the statistical effect, and there's no proof of synergy. The dose, 6 mg/kg, works out to roughly 450 mg for a 75 kg runner, which is a lot. Insomnia, anxiety, headaches, and racing heart showed up more often with caffeine. Here's what the 20-runner study found and who should skip it.
How Much Caffeine Before Lifting? A Meta-Analysis Says 1–2 mg/kg Still Works
The standard advice for caffeine before lifting is 3–6 mg/kg, which can mean several cups of coffee or a heavy scoop of pre-workout. A 2022 meta-analysis of 12 trials found that doses of just 0.9–2 mg/kg still improved muscular strength (d ≈ 0.17), muscular endurance (d ≈ 0.21), and mean bar velocity (d ≈ 0.56). For many lifters, that's about one to two cups of coffee. The effects are modest and the evidence comes from acute, single-session studies, but the findings suggest you may be able to get a similar benefit with less caffeine.