A chili-pepper compound plus caffeine was the only combo that beat placebo over 10 km in a new crossover trial, yet capsaicin alone did nothing. Caffeine drove the statistical effect, and there's no proof of synergy. The dose, 6 mg/kg, works out to roughly 450 mg for a 75 kg runner, which is a lot. Insomnia, anxiety, headaches, and racing heart showed up more often with caffeine. Here's what the 20-runner study found and who should skip it.
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